Peyronies Disease Medical
References:

These are the medical reference materials on Peyronies Disease and Bent Penis Traction Therapy (PTT) that were used to compile this website:

Aaronson DS, Shindel AW. U.S. national statistics on penile fracture. J Sex Med. 2010;7(9):3226. doi: 10.1111/j.1743-6109.2010.01879

Abern MR, Larsen S, Levine LA. Combination of penile traction, intralesional verapamil, and oral therapies for Peyronie's disease. J Sex Med 2012;9:288-95. Erratum in J Sex Med 9:945. [PubMed]

Dr. Abern M., Dr. Levine L., Intralesional injections with and without penile traction and oral therapies for management of Peyronies disease. J Urol 179: 408.

Dr. Michael R. Abern, Dr. Stephen Larsen and Dr. Laurence A. Levine, Combination of Penile Traction, Intralesional Verapamil, and Oral Therapies for Peyronies Disease, The Journal of Sexual Medicine, 9, 1, 288-295, 2011

Aghamir M, Hosseini R., Alizadeh F. (2006) A vacuum device for penile elongation: Fact or Fiction? BJU Int 97: 777–778

Ahuja S et al. A pilot study demonstrating clinical benefit from intralesional interferon alpha 2B in the treatment of Peyronie’s disease. J Androl. 20(4):444-8.

Alenghat F., Ingber D., Mechanotransduction: all signals point to cytoskeleton, matrix and integrins. Sci STKE 2002: PE6.

Alizadeh M, Karimi F, Fallah MR. Evaluation of verapamil efficacy in Peyronie's disease comparing with pentoxifylline. Glob J Health Sci 2014;6:23-30. [PubMed]

Dr. Alman B., Greel D., Ruby L., Goldberg M.J., Wolfe H.J. Regulation of proliferation and platelet-derived growth factor expression in palmar fibromatosis (Dupuytren’s contracture) by mechanical strain. J Orthop Res 14: 722–728

Al-Shaiji TF, Brock GB. Peyronie's disease: evolving surgical management and the role of phosphodiesterase 5 inhibitors. ScientificWorldJournal. 2009;9:822–845

Andromedical Corp./Andropeyronie
“FAQ – Method and Instructions”
The Journal of Sexual Medicine

Androutsos G. Francois Gigot de La Peyronie (1678–1747), benefactor of surgery and supporter of the fusion of medicine and surgery, and the disease that bears his name, Prog Urol. 2002;12(3):527–533

Astorga R et al. Intralesional recombinant interferon alpha-2b in Peyronie’s disease. Arch Esp Urol; 53(7):665-71

Austoni E, Colombo F, Mantovani F, Patelli E, Fenice O. Chirurgia, Radical surgery and conservation of erection in Peyronie's disease. Arch Ital Urol Androl. 1995;67(5):359–364

Dr. Bailey A., Tarlton J., Van der Stappen J., Sims T.J., Messina A. The continuous elongation technique for severe Dupuytren’s disease. A biochemical mechanism. K Hand Surg [Br] 19: 522–527

Bjekic M., Vlajinac H., Sipetic S., Marinkovic J., Risk factors for Peyronies disease: a case control study. BJU Int 97: 570–574

Brake M et al. Treatment of Peyronie’s disease with local interferon-alpha 2b. BJU Int May 2001; 87(7):654-57

Brake M, Keller H, Lamade F, Groh R, Horsch R. Operative Korrektur der Penisdeviation. [Surgical correction of penile deviation. Nesbit vs. Schroeder-Essed method]. Urologe A. 1999;38(3):264–269. doi: 10.1007/s001200050279

Brandes G., Messina A., Reale E., The palmar fascia after treatment by continuous extension technique for Dupuytren’s contracture. J Hand Surg [Br] 19: 528–533

Brighton C., Fisher J., Jr, Levine S., Corsetti J.R., Reilly T., Landsman A.S., et al., The biochemical pathway mediating the proliferative response of bone cells to a mechanical stimulus.J Bone Joint Surg Am 78: 1337–1347

Chitale S, Morsey M, Swift L, Sethia K. Limited shock wave therapy vs sham treatment in men with Peyronie's disease: results of a prospective randomized controlled double-blind trial. BJU Int. 2010;106(9):1352–1356. doi: 10.1111/j.1464-410X.2010.09331

Dr. Chung E., Dr. De Young L., Dr. Brock G. (2011a) Rat as an animal model for Peyronie's disease research: a review of current methods and the peer reviewed literature. Int J Impot Res 23: 235–241

Dr. Chung E., Dr. De Young L., Dr. Brock G. (2011b) The role of PDE5 inhibitor in septal scar remodelling: assessment of the clinical and radiological outcomes. J Sex Med 8: 1472–1477

Dr. Chung E., Dr. De Young L., Dr. Brock G.B. (2012) Penile traction and Peyronies disease: in-vitro analysis of the efficacy of traction on cellular changes in Peyronie’s plaque in a strain culture system. J Sex Med 9(Suppl.2):130

Chung E, Garcia F, Young LD, et al. A comparative study of the efficacy of intralesional verapamil versus normal saline injection in a novel Peyronie disease animal model: assessment of immunohistopathological changes and erectile function outcome. J Urol;189:380-4. [PubMed]

Dr. Eric Chung, Dr. Ling Young, Dr. Matthew Solomon and Dr. Gerald B. Brock, Peyronies Disease and Mechanotransduction: An In Vitro Analysis of the Cellular Changes to Peyronie's Disease in a Cell‐Culture Strain System, The Journal of Sexual Medicine, 10, 5, 1259-1267, 2013

Chung E, Yan H, De Young L, Brock GB. Penile Doppler sonographic and clinical characteristics in Peyronies disease and/or erectile dysfunction: an analysis of 1500 men with male sexual dysfunction. BJU international. 2012;110: 1201-5

Colpi G., Martini P., Scroppo F., Mancini M., Nerva F. (2002a) Treatment with penile retraction in evolutive Peyronie’s disease with external penis-stretching. Int J Impot Res 14(Suppl. 4):S74

Colpi G., Martini P., Scroppo F., Mancini M., Castiglioni F. (2002b) Efficacy of daily penis stretching technique to elongate the ‘small penis’.Int J Impot Res 14(Suppl. 4): S73

Cooper R., Kleinschmidt E., New products: what separates winners from losers. J Prod Innov Manag 4: 169–184

Dr. Dalbin B., Dr. Christopher B., Preservation of penile length after radical prostatectomy: early intervention with a vacuum erection device. Int J Impot Res 19: 501–504

B.L. Dalkin, M.F. CarterVenogenic impotence following dermal graft repair for Peyronie’s disease, J Urol, 146 (1991), pp. 849-851

Dhillon S. Collagenase Clostridium Histolyticum: A Review in Peyronie's Disease. Drugs 2015;75:1405-12. [PubMed]

Dibenedetti DB, Nguyen D, Zografos L, Ziemiecki R, Zhou X. A Population-Based Study of Peyronies disease: Prevalence and Treatment Patterns in the United States. Advances in urology. 2011: 282503

R. DjinovicPenile corporoplasty in Peyronie’s disease: which technique, which graft?, Curr Opin Urol, 21 (2011), pp. 470-477

P.H. Egydio, A.M. Lucon, S. ArapA single relaxing incision to correct different types of penile curvature: surgical technique based on geometrical principles, BJU Int, 94 (2004), pp. 1147-1157

P.H. Egydio, A.M. Lucon, S. ArapTreatment of Peyronie’s disease by incomplete circumferential incision of the tunica albuginea and plaque with bovine pericardium graft, Urology, 59 (2002), pp. 570-574

El-Sakka A., Hassan M., Nunes L., Bhatnagar R.S., Yen T.S., Lue T.F., Histological and ultrastructural alterations in an animal model of Peyronie’s disease. Br J Urol 81: 445–452

El-Sakka AI, Rashwan HM, Lue TF. Venous patch graft for Peyronie's disease. Part II: outcome analysis. J Urol. 1998;160(6 part 1):2050–2053. doi: 10.1016/S0022-5347(01)62240-7

Essed E, Schroeder FH. New surgical treatment for Peyronie disease. Urology. 1985;25(6):582–587. doi: 10.1016/0090-4295(85)90285-7

Garaffa, L. W. Trost, E. C. Serefoglu, D. Ralph
and W. J. G. Hellstrom, Understanding the course
of Peyronie's disease, International Journal of Clinical Practice, 67, 8, 781-788, 2013

Dr. MK Gelbard, Dr. F Dorey, Dr. K James, The natural history of Peyronies disease. The Journal of urology. 1990;144: 1376-9

Gelbard M, Goldstein I, Hellstrom WJ, et al. Clinical efficacy, safety and tolerability of collagenase clostridium histolyticum for the treatment of peyronie disease in 2 large double-blind, randomized, placebo controlled phase 3 studies. J Urol 2013;190:199-207. [PubMed]

Dr. M Gelbard, LI Lipshultz, J Tursi, T Smith, G Kaufman, LA Levine. Phase 2b study of the clinical efficacy and safety of collagenase Clostridium histolyticum in patients with Peyronie disease. The Journal of urology. 2012;187: 2268-74

Gholami SS, Lue TF. Correction of penile curvature using the 16-dot plication technique: a review of 132 patients. J Urol. 2002;167(5):2066–2069. doi: 10.1016/S0022-5347(05)65085-9

Gur S, Limin M, Hellstrom WJ. Current status and new developments in Peyronie’s disease: medical, minimally invasive and surgical treatment options. Expert Opin Pharmacother 2011;12:931-44

K. Hatzimouratidis, I. Eardley, F. Giuliano, D. Hatzichristou, I. Moncada, A. Salonia, et al.EAU guidelines on penile curvature
Eur Urol, 62 (2012), pp. 543-552

Hellstrom WJ et al. Single-blind, multicenter, placebo controlled, parallel study to assess the safety and efficacy of intralesional interferon alpha-2B for minimally invasive treatment for Peyronie’s disease. J Urol Jul 2006; 176(1):394-98

Wegner HE et al. Treatment of Peyronie’s disease with local interferon-alpha 2b. Eur Urol; 28(3):236-40.

Hussein Ghanem, Sidney Glina, Pierre Assalian and Jacques Buvat, Position Paper: Management of Men Complaining of a Small Penis Despite an Actually Normal Size, The Journal of Sexual Medicine, 10, 1, 294-303, 2012

Gholami SS, Lue TF. Correction of penile curvature using the 16-dot plication technique: a review of 132 patients. J Urol 2002;167:2066-9

Dr. P Gontero, M Di Marco, G Guibilei, R Bartoletti, G Pappagallo, A Tizzani, et al, 2008, A pilot phase II prospective study to test the ‘efficacy’ and tolerability of a penile extender device in the treatment of ‘short penis’. BJU Int 103: 793–797

Dr. Paolo Gontero, Massimiliano Di Marco, Gianluca Giubilei, Riccardo Bartoletti, Giovanni Pappagallo, Alessandro Tizzani and Nicola Mondaini, ORIGINAL RESEARCH—Use of penile extender device in the treatment of penile curvature as a result of Peyronie’s disease. Results of a phase II prospective study. J Sex Med 6: 558–566, 2009

Ralph D, Gonzalez-Cadavid N, Mirone V, Perovic S, Sohn M, Usta M, Levine L. The management of Peyronie's disease: evidence-based 2010 guidelines. J Sex Med. 2010;7(7):2359–2374. doi: 10.1111/j.1743-6109.2010.01850

Dr. Gonzalez-Cadavid N., Rajfer J., Mechanisms of disease: new insights into the cellular and molecular pathology of Peyronie’s disease. Nat Clin Pract Urol 2: 291–297

Hauck EW, Mueller UO, Bschleipfer T, Schmelz HU, Diemer T, Weidner W. Extracorporeal shock wave therapy for Peyronie's disease: exploratory meta-analysis of clinical trials. J Urol. 2004;171(2 part 1):740–745. doi: 10.1097/01.ju.0000108060.30363.8d

G.L. Hsu, C.H. Hsieh, H.S. Wen, P.Y. Ling, S.Y. Chen, H.M. Huang, et al.Formulas for determining the dimensions of venous graft required for penile curvature correction, Int J Androl, 29 (2006), pp. 515-520

Illizarov G., Soibeman L., Clinical and experimental data on bloodless lengthening of lower extremities. Eksp Khir Anesteziol 14: 2D–8D

Imbeault A, Bernard G, Ouellet G, Bouhout S, Carrier S, Bolduc S. Surgical Option for the Correction of Peyronie's Disease: An Autologous Tissue-Engineered Endothelialized Graft. J Sex Med. 2011;8(11):3227–3235. doi: 10.1111/j.1743-6109.2011.02374.x

M Jalkut, N Gonzalez-Cadavid, J Rajfer, Peyronies disease: A Review. Reviews in urology. 5: 142-8

Dr. Gerald H. Jordan, Dr. Culley C. Carson and Dr. Larry I. Lipshultz, Minimally invasive treatment of Peyronie's disease: evidence‐based progress, BJU International, 114, 1, 16-24, 2014

Jordan GM, Devine CJ. Surgery of the penis and urethra. In: Walsh PC, et al., editors. Cambell's Urology. 7th ed. Vol. 3. Philadelphia: WB Saunders; 1998. pp. 3316–3394

Kadioglu A, Akman T, Sanli O, et al. Surgical treatment of Peyronie's disease: a critical analysis. Eur Urol 2006;50:235-48

Kadioglu A., Küçükdurmaz F., Sanli O. (2011) Current status of the surgical management of Peyronies disease. Nat Rev Urol 8: 95–106

Kadioglu A, Oktar T, Kandirali E, Kendirci M, Sanli O, Ozsoy C. Incidentally diagnosed Peyronies disease in men presenting with erectile dysfunction. International journal of impotence research. 2004;16: 540-3

Kadioglu A, Sanli O, Akman T, Ersay A, Guven S, Mammadov F. Graft materials in Peyronie's disease surgery: a comprehensive review. J Sex Med. 2007;4(3):581–595. doi: 10.1111/j.1743-6109.2007.00461

Kadioglu A, Tefekli A, Erol B, Oktar T, Tunc M, Tellaloglu S. A retrospective review of 307 men with Peyronies disease. The Journal of urology. 2002;168: 1075-9

Kalsi JS, Christopher N, Ralph DJ, et al. Plaque incision and fascia lata grafting in the surgical management of Peyronie’s disease. BJU Int 2006;98:110-4

Kelami A. Congenital penile deviation and straightening of the penis using the Nesbit-Kelami technique. Urol Int. 1985;40(5):267–268. doi: 10.1159/000281096

Kendirci M., Hellstrom W.J., Critical analysis of surgery for Peyronie’s disease.Curr Opin Urol 14(6):381–388

Kim DH, Lesser TF, Aboseif SR. Subjective patient-reported experiences after surgery for Peyronie’s disease: corporeal plication versus plaque incision with vein graft. Urology 2008;71:698-702

Kohler T., Pedro R., Hendlin K., et al. (2007) A pilot study on the early use of vacuum erection device after radical retropubic prostatectomy. BJU Int 100: 858–862

Kondás J, Diószeghy G, Kondér G, Váczi L, Kiss A, Philipp V. Plaque excision and dermal graft in the surgical treatment of plastic induration of the penis (Peyronie's disease) Int Urol Nephrol. 1998;30(3):321–326

Kovac JR, Brock GB. Surgical outcomes and patient satisfaction after dermal, pericardial, and small intestinal submucosal grafting for Peyronie's disease. J Sex Med. 2007;4(5):1500–1508. doi: 10.1111/j.1743-6109.2007.00453

Laios K, Tsoucalas G, Karamanou M, Androutsos G. Peyronie’s disease in Minoan art. Journal of Sexual Medicine. 2013;10: 3144-5

Lee SS, Meng E, Chuang FP, et al. Congenital penile curvature: long-term results of operative treatment using the plication procedure. Asian J Androl 2004;6:273-6

Dr. Laurence A. Levine and Dr. Arthur L. Burnett, Standard Operating Procedures for Peyronie's Disease, The Journal of Sexual Medicine, 10, 1, 230-244, 2012

Levine LA, Greenfield JM, Estrada CR. Erectile dysfunction following surgical correction of Peyronie’s disease and a pilot study of the use of sildenafil citrate rehabilitation for postoperative erectile dysfunction. J Sex Med 2005;2:241-7

Dr. Levine L., Dr. Newell M., Dr. Taylor F. (2008) Penile traction therapy for treatment of Peyronies disease: a single-center pilot study. J Sex Med 5: 1468–1473

Dr. Laurence A. Levine and James Rybak, Traction Therapy for Men with Shortened Penis Prior to Penile Prosthesis Implantation: A Pilot Study, The Journal of Sexual Medicine, 8, 7, 2112-2117

Dr. L.A. LevineThe clinical and psychosocial impact of Peyronie’s disease
Am J Manag Care, 19 (Suppl. 4) (2013), pp. 55-61

Martinez D, Ercole CE, Hakky TS, et al. Peyronie’s Disease: Still a Surgical Disease. Adv Urol 2012;2012:206284

Dr. Martínez-Salamanca, Juan I., MD, PhD, et al.,
Acute Phase Peyronie's Disease Management with Traction Device: A Nonrandomized Prospective Controlled Trial with Ultrasound Correlation,
Full-text. First published: November 22, 2013

Dr. Martinez-Salamanca JI, Dr. Egui A, Moncada I, et al. Acute phase Peyronies disease management with traction device: a nonrandomized prospective controlled trial with ultrasound correlation. The journal of sexual medicine. 2014;11: 506-15

Juan I Martinez-Salamanca, Lucia Osorio Cabello, Maria Alejandra Egui-Rojo, Estefania Linares Espinos, Efficacy and safety of penile extender device in the treatment of the AP of Peyronie's disease: A pilot study, Journal of Urology, 185(4), April 2011

McCullogh A. (2008) Rehabilitation of erectile function following radical prostatectomy. Asian J Androl 10: 61–74

Moncada-Iribarren I., Jara J., Martinex-Salamanca J., Cabello R., Hernandez C. (2007) Managing penile shortening after Peyronies disease surgery. J Urol 177 (Suppl. 4): 252

Daniel J. Moskovic, Alexander W. Pastuszak, Larry I. Lipshultz and Mohit Khera, Revision of penile prosthesis surgery after use of penile traction therapy to increase erect penile length: Case Report and Review of the Literature, Journal of Sexual Medicine, 8, 2, 607-611, 2010.

Dr. Mulhall JP, Dr. Schiff J, Dr. Guhring P. An analysis of the natural history of Peyronies disease. The Journal of urology. 2006;175: 2115-8; discussion 18

Nehra A, Alterowitz R, Culkin DJ, et al. Peyronie’s disease: AUA Guideline. AUA; 2015

CJ Nelson, C Diblasio, M Kendirci, W Hellstrom, P Guhring, JP Mulhall. The chronology of depression and distress in men with Peyronies disease. The Journal of Sexual Medicine. 2008;5

Dr. Christian J. Nelson and Dr. John P. Mulhall, Psychological Impact of Peyronie's Disease: A Review, The Journal of Sexual Medicine, 10, 3, 653-660, 2012

Mohammadreza Nikoobakht, Alireza Shahnazari, Maedeh Rezaeidanesh, Abdolrasoul Mehrsai and Gholamreza Pourmand, Effect of penile‐extender device in increasing penile size in men with shortened penis: preliminary results, J of Sexual Medicine, 8, 11, 3188-3192, 2010

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Nowroozi MR, Amini E, Ayati M, Jamshidian H, Radkhah K, Amini S. Applying extender devices in patients with penile dysmorphophobia: assessment of tolerability, efficacy, and impact on erectile function. The journal of sexual medicine. 2015;12: 1242-7

Dr. Oderda M, Dr. Gontero P. Comment on: applying extender devices in patients with penile dysmorphophobia: assessment of tolerability, efficacy, and impact on erectile function. The journal of sexual medicine. 2015;12: 1248

Pryor J., Ralph D. (2002) Clinical presentations of Peyronie's disease. Int J Impot Res 14: 414–417

Qian A., Meals R., Rajfer J., Gonzalez-Cadavid N. (2004) Comparison of gene expression profiles between Peyronie’s disease and Dupuytren contracture. Urology 64: 399–404

Raheem A., Garaffa G., Raheem T., Dixon M., Kayes A., Christopher N., et al., (2010) The role of vacuum pump therapy to mechanically straighten the penis in Peyronie’s disease. BJU Int 106: 1178–1180

Raina R., Agarwal A., Ausmundson S., Lakin M., Nandipati K.C., Montague D.K., et al., Early use of vacuum constriction device following radical prostatectomy facilitates early sexual activity and potentially earlier return of erectile function. Int J Impot Res 18: 77–81

Dr. David Ralph, Nestor Gonzalez‐Cadavid, Vincenzo Mirone, Sava Perovic, Michael Sohn, Mustafa Usta and Laurence Levine, Trauma, Gender Reassignment, and Penile Augmentation, The Journal of Sexual Medicine, 7, 4pt2, 1657-1667, 2010

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Ralph D., Gonzalez-Cadavid N., Mirone V., Perovic S., Sohn M., Usta M., et al. (2010) The management of Peyronies disease: Evidence-based 2010 guidelines. Journal Sex Med 7: 2359–2374, 2010

EL Rhoden, CE Riedner, SC Fuchs, EP Ribeiro, G Halmenschlager. A cross-sectional study for the analysis of clinical, sexual and laboratory conditions associated to Peyronie’s disease. Journal of sexual medicine, 2010;7: 1529-37

Dr. Brian Richardson, Dr. Michael R. Pinsky and Dr. Wayne J.G. Hellstrom, Continuing Medical Education: Incision and Grafting for Severe Peyronies Disease (CME), Journal Sexual Medicine, 6, 8, 2084-2087, 2009

Safarinejad M., Asgari M., Hosseini S., Dadkhah F. (2010) A double-blind placebo-controlled study of the efficacy and safety of pentoxifylline in early chronic Peyronie’s disease. BJU Int 106: 240–248

S. Sansalone, G. Garaffa, R. Djinovic, S. Pecoraro, M. Silvani, G. Barbagli, et al.Long-term results of the surgical treatment of Peyronie’s disease with Egydio’s technique: a European multicentre study, Asian J Androl, 13 (2011), pp. 842-845

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Scroppo F., Mancini M., Maggi M., Colpi G. (2001) Can an external penis stretcher reduce Peyronies penile curvature? Int J Impot Res 13(Suppl. 4): S21

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Dr. Valente E., Vernet D., Ferrini M., Qian A., Rajfer J., Gonzalez-Cadavid N.F. (2003) L-arginine and phosphodiesterase (PDE) inhibitors counteract fibrosis in the Peyronies fibrotic plaque and related fibroblast cultures. Nitric Oxide 9: 229–244

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